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This feature and its negative charge at physiological pH imply the existence of specific carriers to import GSH from the cytosol to the mitochondrial matrix, where it plays a key role in defense against respiration-induced reactive oxygen species and in the detoxification of lipid hydroperoxides and electrophiles
Moreover, neutralizing these charges enhanced the inhibitory activity of the peptides against FOXO4 FHD and p53 TAD
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Inside the package: a Certificate of Analysis specific to the shipped lot (covering HPLC, mass spectrometry, and LAL endotoxin), a Safety Data Sheet, and a brief handling reference
The repair signature is reminiscent of the copper signature very recently demonstrated in regulatory T cells, whose energetic and functional phenotype is highly dependent on free intracellular copper
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