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These mechanisms are the basis for the highly efficacious GLP-1 analogues that today offer safe and effective treatment in millions of people living with obesity
In addition, all included studies were randomized controlled trials
However, the mechanisms through which this occurs are poorly defined
Chow E, Wang K, Lim CKP, Tsoi STF, Fan B, Poon E, et al (2023) Dorzagliatin, a dual-acting glucokinase activator, increases insulin secretion and glucose sensitivity in glucokinase maturity-onset diabetes of the young and recent-onset type 2 diabetes
Theoharides et al., 2008
However, the results demonstrate that high-efficiency linear SPPS remains highly competitive for GLP-1-like peptides
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