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Mitochondrial dysfunction is a critical factor in the progression of heart failure
Top left, engagement of the peptide with the receptor ECD releases ECD constraints on the transmembrane domain promoting outward movements of TM1, TM6 and TM7 by peptide
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doi:10.3390/ph17040461 McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM