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Pushing doses up too fast is the single biggest cause of dropping out

An earlier injection is generally not considered medically necessary

Ascorbic acid aids in the absorption of dietary iron, particularly non-heme iron found in plant-based foods, by converting it into a more absorbable form and increasing its bioavailability

Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

J Transl Med (2021) 19:81

Over time, perifollicular fibrosis essentially chokes off follicle function