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Instead of compelling an abnormal reaction, they repair a damaged signal

At the same time, the laser stimulates collagen production, which helps tighten the skin in the treated areas

This could be due to a Zn-induced inhibition of phosphatase activity, leading to Mitogen-activated protein kinase (MAPK) and activator protein-1 (AP-1) activation, resulting in the enhanced IL-8 expression [140]

During this window, substances applied to the skin surface can penetrate directly to the dermis at concentrations that approach injectable delivery

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Dig Dis Sci 38: 665-673, 1993