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In humans, GH secretion during early sleep may be nearly totally suppressed by administration of a specific GHRH antagonist ( Growth hormone injections are traditionally timed to align with the natural circadian rhythms of GH secretion, typically during the early night, to coincide with the onset of slow-wave sleep ( We hypothesized that daily GH injections given in the evening could disrupt sleep both by inhibiting GHRH secretion, and due to the discomfort and psychological distress associated with the injection and local reactions

Using lower doses of semaglutide is cheaper for patients, results in fewer side-effects and helps ensure that stocks of the drug, which are still limited, go further. Tapering semaglutide 353 of the 2,246 patients (83% female, median age 49 years, median BMI 31.5, average body weight 92kg/14st 7lb) started to taper off semaglutide after they had reached their target weight

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