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Glucagon-like peptide-1 ( GLP-1 ) receptor agonists, such as semaglutide (Wegovy) or tirzepatide (Zepbound), reduce hunger and cravings, making it easier to maintain a calorie deficit during plateaus

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The big scary life-shortening ones, like metabolic disease

The American Journal of Clinical Nutrition, 104(2), 362370

It activates AMP-activated protein kinase (AMPK), a key metabolic regulator, and influences glucose and lipid metabolism through multiple pathways