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Compounded semaglutide is typically safe for most people, too, but there are no clinical trials backing this up
Jump to: Who should never take weight-loss injections | Conditions that need extra caution | Medications that interact | Pregnancy, breastfeeding and age | If you are scheduled for surgery | When to stop and seek help | Questions to ask your GP | Frequently asked questions | Take home message You shouldnt take weight-loss injections like Wegovy (semaglutide) or Mounjaro (tirzepatide) if you have a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2 (MEN-2), type 1 diabetes, or have had a serious allergic reaction to a GLP-1 medication
This often coincides with the peak gastrointestinal side effect period and likely reflects the physical discomfort and dietary restrictions rather than a direct medication effect
Most clinical trial data spans 1268 weeks, leaving questions about multi-year safety profiles unanswered
2011 Apr 30;377(9776):1494