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Consistent with this, our preclinical work uncovered that TMAO primed renal fibroblasts for conversion to myofibroblasts, the primary collagen-producing cells in the kidney 46 , and contributed to renal fibrosis, a hallmark of kidney damage irrespective of the underlying cause that significantly contributes to eGFR decline 46

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These usually reduce over time as the body adjusts to the medication

For most people, the answer to that question is no. But a surprising number of people are willing to pay hundreds of dollars out of pocket each month, Moore said

Therefore, depending on the origin and the differentiation stage, DC could exert either pro- or anti-angiogenic functions