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Additionally, metformin has been shown to be effective in reducing pregnancy-related complications in patients with PCOS, including gestational diabetes, hypertension, and preeclampsia

2.2 Characteristics of pharmacokinetics AS-IV demonstrates pronounced linear pharmacokinetic properties in preclinical studies

The gut permeability is increased, and the harmful materials (such as endotoxins) are systemically translocated due to the intestinal barrier damage