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Taken orally, glutathione has inherently low bioavailability as it faces two key obstacles: the strong acidity of gastric juices and the action of a liver enzyme called gamma-glutamyltranspeptidase (GGT) which catalyses the first stage of its breakdown (8)
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The literature on NAC rescue for acetaminophen overdose makes it clear that early rescue is important[10, 55, 56]