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These programs reflect a broader movement toward combination pharmacology, where multiple complementary biological pathways are investigated simultaneously rather than individually
GLP-1 exists in the human body in two active forms, GLP-1 (7-36 amide) and GLP-1 (7-37), with the proportion of GLP-1 (7-36 amide) being higher
They include: feeling or being sick diarrhoea constipation These side effects are more likely to occur when the treatment first starts or when the dose increases

DOI: Published online: August 18, 2021 1 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, College of Medicine, Rochester, MN, USA 2 Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN, USA 3 Department of Psychiatry and Psychology, Mayo Clinic, College of Medicine, Rochester, MN, USA 4 Department of Neuroscience Program, Mayo Clinic, College of Medicine, Rochester, MN, USA Corresponding author: Doo-Sup Choi, PhD Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, College of Medicine, Rochester, 200 1st SW, MN 55905, USA / Tel: +1-507-284-5602 / Fax: +1-507-266-0824 / E-mail: [email protected] Copyright 2021 The Korean Movement Disorder Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited