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Darmstadt, Germany) or Honeywell (Seelze, Germany), formic acid and ammonium bicarbonate for LC-MS from Honeywell, dithiothreitol (DTT) from Pierce Biotechnology (Rockford, IL, United States), iodoacetamide from Sigma-Aldrich (St

The blend is well tolerated, with gastrointestinal effects being the most frequent adverse events and no evidence of clinically significant safety concerns or neutralizing antibody responses to cagrilintide during short-term exposure 1-3

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It produced an average weight loss of 22.7% over 68 weeks in its Phase 3 REDEFINE 1 trial, the highest reported for any Novo Nordisk obesity drug to date

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During fasting and diabetic ketosis, serum acetone, acetol, and 1,2-propanediol are elevated