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For decades, it has been known that female kidneys are less sensitive to AKI 5,6

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doi: 10.1016/j.cgh.2019.12.032 Summary Keywords ulcerative colitis, mitochondria, immune infiltration, metabolism, bioinformatics analysis, machine learning, unsupervised clustering Citation Zhang Y, Fan M, Bai Q, Zhao R, Song S, Wu L, Lu J, Liu J, Wang Q, Li Y and Chen X (2024) Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironment

We propose a model wherein SYK upregulation serves as a compensatory mechanism that bolsters SC metabolic capacity, fulfilling a dual role: (1) it promotes SC survival by maintaining bioenergetic homeostasis and mitigating mitochondrial damage under stress, thereby preventing glial apoptosis