It's to build the pathway that lets us generate it, under real oversight, with patients protected the whole way
A practical starting point before moving into more targeted therapies
A variety of stimuli can accelerate the accumulation of this pigment, such as drug and chemical exposure, trauma and circulatory factors, and diet (Greaves 2007)
Pralatrexate: 1 (milligram) mg of vitamin B12 as an injection no more than 10 weeks prior to the first dose and every 8 to 100 weeks thereafter
In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, editors
Others split the weekly dose into two injections to reduce injection volume and potentially improve absorption consistency