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Mitochondria adjacent to the oligomers exhibited disrupted membranes, whereas mitochondria that were remote from the aggregates were relatively normal

Jan 2015;28(1):4-10

Moreover, in the motor cortex of ALS patients, the levels of NRF2 mRNA and protein were reduced, whereas Keap1 mRNA expression was increased compared to control patients (Sarlette et al., 2008