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Use of medications that affect blood sugar (insulin, GLP-1s, steroids)

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The peptide's upregulation of VEGFR2 at both mRNA and protein levels sensitizes healing tissues to angiogenic signals while its activation of the Src-Caveolin-1-eNOS pathway generates nitric oxide essential for vascular development and tissue perfusion

Different from the former studies, the Ala222Val variant exhibits identical catalytic properties as the wild-type enzyme, but it is thermolabile 17

S.ChiuS.JiaX.et al (2019)