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doi:10.1124/jpet.114.222356
The full TRIUMPH program enrolled more than 5,800 participants across multiple Phase 3 trials
Malaguarnera ( Tnf, Il6, Il1b ) and downregulates pro-fibrotic genes ( Acta2, Col1a2, Tgfb1, Pdgfrb, Pdgf-b, Pdgf-c ), reducing -smooth muscle actin (-SMA) and platelet-derived growth factor receptor beta (PDGFR) protein levels ( The anti-inflammatory and anti-fibrotic properties of L-carnitine underscore its potential to halt MASLD progression to advanced stages
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