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Apart from this, the restricted penetration of NPs is also a result of heterogenous tumor microenvironment, phenomena like the vasculogenic mimicry (formation of vessel-like structures by tumor cells which is independent of endothelial cells), hypoxic regions which limits the efficacy of therapies targeting vasculature thereby impairing drug activation

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TNF-cell surface death receptors, which cause apoptosis, are expressed in renal tubular cells (Feldenberg et al

et al., 2021)

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Additionally, the use of a wide range of AOXs (either single or in combinations) and the lack of standardized dosages in different studies preclude the ability to draw a firm conclusion on the efficacy of AOX supplementation in solving infertility problem