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For patients trying to conceive, they are advised to continue using contraception for a defined wash-out period, i.e

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Diabetes Care 47 (11), 18731888

[7] Interestingly, in 2020, I came off all of my supplements (including methylation-supportive ones) during the lockdown, as my support system virtually vanished overnight and I was providing 24/7 care to my toddler son, who was still waking up at night

No increase in dose-dependent gastrointestinal adverse events was observed