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While these skin reactions are generally considered normal and temporary, some people may find them bothersome or concerning

Adverse Reactions: Acute gallbladder disease Acute kidney injury Acute pancreatitis Diabetic retinopathy complications in patients with type 2 diabetes mellitus suicidal behavior and ideation Hypersensitivity reactions Hypoglycemia Pulmonary aspiration during general anesthesia or deep sedation Risk of thyroid C-cell tumors Severe gastrointestinal adverse reactions The most common adverse reactions, reported in 5% of patients treated with Zepbound are: nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection site reactions, fatigue, hypersensitivity reactions, eructation, hair loss, and gastroesophageal reflux disease

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These events occurred at similar rates in placebo groups, suggesting they may not be directly attributable to the peptide

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All peptides were provided by the Novo Nordisk Research Center Indianapolis, and have been previously validated in vitro and in vivo for receptor specificity and their ability to decrease body weight in DIO mice 13,14,15,22,41