The groups most likely to develop B12-related hair and skin changes are the same ones at risk for deficiency generally: vegans and vegetarians, adults over 50, people on long-term metformin or proton pump inhibitors, anyone who's had bariatric surgery, and people on GLP-1 protocols whose reduced appetite has significantly lowered their overall nutrient intake for an extended period
10.1016/j.molcel.2022.03.022 Mol
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Table 10: Analyses of the Primary and Secondary Endpoints and their Individual Components in FLOW Trial 1 Cox proportional hazards model with treatment as factor and stratified by baseline use of SGLT2-inhibitor at baseline (yes or no)
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Neurosci Appl 3:103925 Leggio L, Hendershot CS, Farokhnia M et al (2023) GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders