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The high levels of insulin have been shown to reduce the levels of the Insulin-like growth factor (IGF) binding protein, which can tightly bind to IGFs, resulting in excessive free IGF-1 in cells and tissues
People with IBS, especially those with constipation-predominant symptoms or a history of post-infectious IBS, may already have altered gut motility, which could increase vulnerability
Michel, F
4 SinghSGeorgeJBolandBSVande CasteeleNSandbornWJ
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Kharb S et al
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