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Results Starting SGLT-2 inhibitor treatment was associated with a lower rate of hyperkalemia than DPP-4 inhibitor treatment (hazard ratio 0.75, 95% confidence interval (CI) 0.73 to 0.78) and a slight reduction in rate compared with GLP-1 receptor agonists (0.92, 0.89 to 0.95)

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Either direction would significantly impact the peptide landscape

Results Search and risk of bias Of the 54 articles assessed for eligibility, 23 RCTs (References 123 in the Additional file 1) fulfilled the inclusion criteria and were included in the meta-analysis (Additional file 1: Fig

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