Participants were randomized 1:1:1 to retatrutide 9 mg weekly, retatrutide 12 mg weekly, or placebo, with treatment lasting 68 weeks
Genetic testing and provider consultations are separate
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The cardiovascular evidence from the SOUL trial is reassuring and places it firmly alongside injectable GLP-1 agonists as a cardioprotective option in high-risk patients with diabetes
A balanced diet rich in whole foods, fruits, vegetables, lean proteins, and whole grains can enhance the effectiveness of Semaglutide and promote sustainable weight loss
And when side effects persist beyond the typical 4-6 week adjustment period, switching to an alternative with a different receptor binding profile or mechanism of action often resolves the issue entirely