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While medications that reduce alcohol intake such as naltrexone and acamprosate have central nervous system action, disulfiram reduces alcohol intake through peripheral mechanisms

Widespread use of these agents requires systematic perioperative strategies by anaesthetists to balance safety with therapeutic benefit

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Therefore, CB-839 has been tested in many clinical trials, including colorectal cancer (NCT02861300), triple-negative breast cancer (NCT02071862), renal cell carcinoma (NCT03163667), melanoma (NCT02771626), and others (Table 2)

Clinical studies show that 87.3% of patients lose at least 5% of their weight, while more than half achieve a 10% or greater reduction