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Spatial transcriptomics combined with Slingshot pseudo-time analysis revealed the migration trajectory of VSMC within the vascular wall: VSMC radially migrate from the media to the intima, differentiate into plaque-associated fibrocytes after passing through a myofibrillar intermediate state, and exhibit a spatial trajectory highly correlated with the gene expression gradient of ECM remodeling
Research has shown that GLP-1 medications may help address elevated blood pressure, high blood sugar and insulin resistance, and even sleep apnea ( 6 )
Development 141 , 10111021 (2014)
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The plaques, the scaling, the redness, those are downstream consequences of an immune system that has lost the ability to distinguish between genuine threats and the body own tissue
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