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Human clinical trials present mixed and modest results

However, many patients experience improved fat metabolism over time due to: Better insulin sensitivity Reduced visceral fat storage Improved metabolic flexibility These changes can support more efficient fat utilization, even without a measurable rise in thermogenesis

Given that pyruvate is a major source of acetyl-CoA for lipid (fatty acids, cholesterol, etc.) biosynthesis, the role of pyrimidines in pyruvate production is critical for overall lipogenesis