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investigated the effectiveness of acetyl-l-carnitine in 28 patients with painful radiculopathies and neuropathies, including 17 with chronic lumbar radiculopathy, unresponsive/poorly responsive to previous treatment ( 30% pain relief) [50, 51]
Another Se-dependent enzyme, thioredoxin reductase (TXNRD), supports antioxidant defense by maintaining the redox balance in thyroid cells [17]
The most commonly reported side effects were gastrointestinal, including nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation
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It is caused by genetic mutations that lead to a deficiency of the glucocerebrosidase (GCase) enzyme
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