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Acute ulcer healing might respond to 4-6 week intensive protocols, while comprehensive gut barrier restoration could require 12+ weeks

Lingvay I, Cheng AY, Levine JA, Gomez-Valderas E, Allen SE, Ranta K, Torcello-Gomez A, Thieu VT (2023) Achievement of glycaemic targets with weight loss and without hypoglycaemia in type 2 diabetes with the once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist tirzepatide: a post hoc analysis of the SURPASS-1 to -5 studies

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Clinical trials for retatrutide are designed with rigorous safety monitoring protocols to detect both short- and long-term adverse effects