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Pregnancy and breastfeeding: Use is not recommended in pregnancy or whilst breastfeeding, as safety data are not yet available

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Subcutaneous injection bypasses all three problems at once: it avoids gastric acid and pancreatic enzymes, sidesteps the intestinal wall, and delivers the peptide to a well-perfused space from which it diffuses into circulation

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However, damage to this barriersometimes referred to as intestinal permeability or leaky gutcan allow inflammatory compounds such as bacterial endotoxins to enter the bloodstream

The treatment of ASD remains challenging due to its etiological heterogeneity and the limited efficacy of current pharmacological interventions (Masi et al