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If youve spent time scrolling through social media, you may have heard of the supplement berberine, which is being touted as natures Ozempic. On TikTok, videos describing the benefits of berberine have been viewed 127 million times and include several claims about how it can help you lose weight, lower your cholesterol, and treat insulin resistance
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In one study, individuals treated with Semaglutide lost an average of 9-13 percent of their body weight over the course of a year without making any changes to their diet and exercise habits
Remarkably, compromised mitochondrial function in ClpP IEC mice, as well as inhibition of mitochondrial respiration using oligomycin in murine and human organoid cultures was sufficient to reduce EEC marker gene expression, indicating a causative role for metabolism in steering differentiation into this IEC subtype
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