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This means some lipid improvement occurs even in participants who lose minimal weight, though greater weight loss produces greater lipid improvement

The trial enrolled 76 adults with type 2 diabetes and randomized them to placebo, a three-strain formula or the five-strain formula now sold as Glucose Control After 12 weeks, the group taking the five-strain probiotic saw a statistically significant improvement in post-meal blood sugar spikes and total glucose response after a test meal compared with the placebo group

doi: 10.3389/fphar.2026.1856307 Received 15 April 2026 Revised 25 May 2026 Accepted 27 May 2026 Published 17 June 2026 Volume 17 - 2026 Edited by Carlos Rodrguez-Nogales, Universidad Complutense de Madrid, Spain Reviewed by Madhusudan Prasad Singh, All India Institute of Medical Sciences, Deoghar (AIIMS Deoghar), India Alessandro Conforti, Nephrology Unit, ASL Roma 4, Italy Updates Copyright 2026 Wu, Lei, Sa, Zhong and Lu

[42] This opened the door to the discovery of the glucagon-like peptide-1 receptor and then drugs which target that receptor, known as GLP-1 receptor agonists

It does not interact with cytochrome P450 enzymes in the liver, which means fewer drug interaction concerns than many other medications

Similarly, tirzepatide's SURMOUNT trials included more than 5,000 participants