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Systemic tissue repair potential Beyond cosmetic applications, GHKs ability to accelerate tissue repair has been documented across multiple tissue types in research settings including bone tissue, lung connective tissue, liver, and gastrointestinal tract lining

TABLE 4 Mechanism of action and level of observed therapeutic benefits of semi-synthetic and synthetic AT mentioned in this review

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Gu S, Shi J, Tang Z, et al

Higher doses or additional medications Repeated injections without sustained improvement Increasing side effects with diminishing therapeutic return At this stage, pain is no longer simply a symptomit reflects underlying regulatory imbalance

10.3803/EnM.2023.1764 191 KoneckeL