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Juan CA, de la Prez JM, Plou FJ, Prez-Lebea E

The review synthesized findings from cell-culture experiments (human dermal fibroblasts, keratinocytes, irradiated fibroblasts), animal models (rats, mice, pigs, dogs), and human cosmetic-science studies of topical formulations

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The exact dose and duration are tailored to the severity of the infection and whether the treatment is for an initial outbreak, recurrent episode, or suppressive therapy