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Agonists of the GLP-1 receptor have been shown to increase levels of markers of bone formation (osteocalcin and procollagen type 1 N-terminal propeptide [P1NP]) and protect against loss of bone mineral content in obese women after weight loss while having no effect on plasma CTX-1 concentrations [59, 60]
Its difficult to pinpoint exactly how they behave, because the mechanisms by which they work are still not exactly known
By weighing different residues adopted in each position, the activity of a dual agonist could be customized
This includes individuals with a history of myocardial infarction, coronary revascularization, heart failure (particularly with reduced ejection fraction), significant valvular disease, or documented arrhythmias
doi: 10.2174/138945006777435290 93 FrstermannUSessaWC