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Factors such as your metabolism, genetic predisposition, lifestyle habits (like diet, exercise, and sleep), and individual response to B12 can all influence the timeline for experiencing improvements

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This point could be elucidated by the lack of response to B12 treatment in congenital methylmalonic aciduria resultant from MMUT gene mutations

A study of 100 patients diagnosed with plantar fasciitis randomly split into two treatment groups was published in August 2025

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