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If more than 3 days have passed since the last dose, reinitiate Xultophy at the recommended starting dose to mitigate GI side effects

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The evidence on intermittent use of GLP-1 receptor agonists is limited, and decisions should be individualized based on your specific health needs and response

If your A1C drops quickly or we see early signs of retinopathy worsening, we increase monitoring frequency

Accessed April 9, 2026

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