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The addition of glucagon receptor agonism raises theoretical considerations around heart rate elevation , and Phase 2 data did show modest increases in resting heart rate in some participants a finding that will require careful monitoring in Phase 3 cardiovascular outcome trials

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00:11:13 Steve Small: Yeah

In a recent trial, patients taking the pill lost an average of 13.6% of their body weight after 64 weeks, compared to about 2% for the placebo group

Over 72 weeks, average weight loss was: 5 mg dose: 15.0% of body weight 10 mg dose: 19.5% of body weight 15 mg dose: 20.9% of body weight Placebo: 3.1% of body weight About 91% of participants on the 15 mg Zepbound dose lost at least 5% of their body weight, and more than half lost 20% or more