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Int J Nanomed 16:249268 Ilari A et al (2012) A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

doi:10.1111/1471-0528.15153

Targeting A 2A R with classic pharmacology has shown some drawbacks, including slow and imprecise drug delivery and low specificity and efficacy [21]

However, we acknowledge that studies with conflicting or non-replicable findings are equally important and should be included in comprehensive future analyses

Consistency, proper application, and realistic expectations play a major role in how effective any topical product can be

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