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The extended activity duration increases the window during which adverse effects could manifest

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Author et al

Exclusion criteria included any current or prior conditions affecting other bodily systems, such as familial hypercholesterolemia, severe cardiovascular and cerebrovascular diseases (e.g., myocardial infarction, stroke, and heart failure), respiratory diseases, infectious diseases, chronic kidney disease, pregnancy, and malignancies

Additionally, the bidirectional relation between neuroinflammation and neuronal injury requires further investigation

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