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In clinical practice, the degree of weight loss with lifestyle intervention is only moderate, and the success rate 2 years after onset of an intervention is low ( 40% reached a category below the obesity threshold [14]
In one phase 2 trial of people with obesity, some of whom also had type 2 diabetes, participants lost 20.5% of their fat mass while increasin g their lean muscle mass by 3.6% over 48 weeks of treatment
But with rapid weight loss comes certain aesthetic side effects
Lyophilized stability: Up to 36 months at -20C in a sealed vial protected from light and moisture
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The FDA also raised concerns about contamination, incorrect dosages, unapproved or harmful ingredients, and counterfeit components in compounded GLP-1s
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