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57 SeiwerthS.RucmanR.TurkovicB.SeverM.KlicekR.RadicB.et al (2018)
First, it gets in the way of your digestive system's ability to absorb B vitamins from the food you eat
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It also makes the vial harder to access cleanly when drawing doses
Over the years, countless preclinical studies (primarily in animal models) have explored its effects on various tissue types
Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision
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