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Furthermore, GSH depletion did not change protein levels of oxidative phosphorylation (OXPHOS) complexes in liver under HFD (Figure 4H), and it did not alter mitochondrial respiration in hepatocytes (Figure 4, I and J)

Mass spectrometry can support identity confirmation, but a matching mass alone does not characterize sequence-related impurities, positional isomers, disulfide variants, aggregates, residual reagents, or all degradation products

finalized assay values are not shown until lot-specific documentation is available.

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However, N-acetylcysteine (NAC), a glutathione precursor, has the strongest clinical evidence and is used in NHS hospitals, making it a more reliable option despite not being a direct glutathione supplement

The increased expression of Bcl-2, and more precisely the unfavorable ratio of the pro-apoptotic Bax protein to the anti-apoptotic Bcl-2 protein, determines the high resistance of this tumor to chemotherapy