Not even a single case could be found in some populations where more traditional diets are eaten (i.e., minimally processed, high-carb, low-fat diets)
Fortunately, there are some strategies that might help in bringing that total down
This dose ceiling was established through the STEP clinical trial series, which involved over 4,500 adults with obesity
If you are on 60 to 70 mg or are sleep-sensitive, consider taking half the dose (open the capsule and dissolve half the powder in water, per FDA-approved administration instructions) or skipping entirely [4]
It supports mood, muscle mass, bone health and long-term metabolic health
Furthermore, macrophages regulate T cell polarization through the secretion of IL-10, and abnormally activated T cells further amplify pulmonary inflammation (Willis et al., 2018)