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This was completely abolished by liraglutide treatment, leading to blood glucose levels lower than those observed in WT PBS-treated mice ( Figures 1I, J )

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Pharmacological GLP-1RA Action Key Mechanistic Distinctions A comprehensive review published in Cell Metabolism reviewed circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1R-positive cell types and pathways transducing metabolic and non-glycaemic GLP-1 signals

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