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However, the incidence of gastrointestinal events, discontinuations due to adverse events, and mean increase in pulse rate were higher with orforglipron than oral semaglutide

It is most often seen during the early stages of treatment or after dose increases, which is why gradual titration is a central part of the dosing strategy used in clinical studies

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You may discuss whether to continue or discontinue the drug, depending on the severity of your symptoms