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This fatty acid moiety enables reversible, non-covalent albumin binding in the systemic circulation, dramatically extending plasma half-life relative to both native amylin and earlier pramlintide analogues

10.1002/hep.510290213 39 GustafsonE

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Gastrointestinal side effects (diarrhoea, nausea, abdominal discomfort) are common with both agents and may be additive when used together

It is important to distinguish normal injection site reactions from signs of infection or allergic response