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Monitor Bone Density: Discuss bone density screenings with your doctor, as rapid weight loss can impact bone mass in seniors

Decision Guidance Choose cagrilintide + tirzepatide when you want the strongest single-agent base (tirzepatide is FDA-approved and outperforms semaglutide head-to-head) plus amylin layering

Eligibility was also dependent on first prescription of the GLP-1 RA of interest (either as monotherapy or part of combined therapy) during the selection window

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Most of these medications are administered through subcutaneous injections, meaning they are injected just under the skin

This makes them useful for a balanced eating plan