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Individuals with an active malignancy or a relevant personal history of cancer, given BPC-157's angiogenic action
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in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation
Preclinical studies suggest involvement in: Angiogenesis Nitric oxide modulation Tendon and ligament repair Muscle regeneration Gastrointestinal protection Due to these findings, BPC-157 is often regarded in research circles as one of the most effective peptides for experimental tissue repair models
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